Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK7 | Q8TDX7 | 11/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096584 | 1.00 | NEK7 (0.40) | NEK7BRAFKITPDGFRBFLT3 | |
| SCHEMBL24096709 | 0.83 | NEK7 (0.48) | NEK7BRAFKITFLT3KDR | |
| SCHEMBL30320639 | 0.83 | NEK7 (0.48) | NEK7BRAFKITFLT3KDR | |
| SCHEMBL30320496 | 0.81 | NEK7 (0.52) | NEK7 | |
| SCHEMBL24096724 | 0.81 | NEK7 (0.52) | NEK7 | |
| SCHEMBL23966757 | 0.81 | NEK7 (0.56) | NEK7 | |
| SCHEMBL30180828 | 0.81 | NEK7 (0.56) | NEK7 | |
| SCHEMBL24096641 | 0.76 | TP53 (0.41) | CYP1A2CYP3A4CYP2C19USP2ALDH1A1 | |
| SCHEMBL29998774 | 0.76 | TP53 (0.41) | CYP1A2CYP3A4CYP2C19USP2ALDH1A1 | |
| SCHEMBL24096462 | 0.74 | NEK7 (0.60) | NEK7KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161933-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |