SCHEMBL30325836

SCHEMBL30325836

C=CC(=O)Nc1ccc(-c2nn3ncnc(N)c3c2-c2ccc(C(=O)NC3CC(O)C3)c(OC)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 9/20 0.47
▸ CSNK2A1 P68400 9/20 0.47
▸ BTK Q06187 5/20 0.37
▸ GAK O14976 1/20 0.36
▸ TNK2 Q07912 2/20 0.36
▸ EGFR P00533 2/20 0.35
▸ MALT1 Q9UDY8 1/20 0.34
▸ CCNK O75909 1/20 0.34
▸ CCNA2 P20248 1/20 0.34
▸ CDK2 P24941 1/20 0.34
▸ CDK7 P50613 1/20 0.34
▸ CCNH P51946 1/20 0.34
▸ MNAT1 P51948 1/20 0.34
▸ CDK12 Q9NYV4 1/20 0.34
▸ TEC P42680 1/20 0.34
▸ TXK P42681 1/20 0.34
▸ BMX P51813 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29265856 1.00 CSNK2A2 (0.47) CSNK2A2CSNK2A1BTKGAKTNK2
SCHEMBL30325999 0.94 CSNK2A2 (0.43) CSNK2A2CSNK2A1BTKGAKTNK2
SCHEMBL29265741 0.94 CSNK2A2 (0.43) CSNK2A2CSNK2A1BTKGAKTNK2
SCHEMBL29265840 0.94 CSNK2A2 (0.50) CSNK2A2CSNK2A1BTKTNK2
SCHEMBL29265926 0.92 CSNK2A2 (0.47) CSNK2A2CSNK2A1BTKTNK2
SCHEMBL29265813 0.92 CSNK2A2 (0.47) CSNK2A2CSNK2A1BTKTNK2EGFR
SCHEMBL29265709 0.91 CSNK2A2 (0.43) CSNK2A2CSNK2A1BTKGAKTNK2
SCHEMBL29265769 0.91 CSNK2A2 (0.47) CSNK2A2CSNK2A1BTKTNK2EGFR
SCHEMBL29265797 0.90 CSNK2A2 (0.42) CSNK2A2CSNK2A1BTKGAKTNK2
SCHEMBL30325956 0.86 GAK (0.40) CSNK2A2CSNK2A1BTKGAKTNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2024-11-21 — — US claimed
EP-4405358-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H Pharmaceuticals Co., Ltd. (CN) 2024-07-31 — — EP claimed
CN-118043327-A FGFR inhibitors and methods of use thereof 思康睿奇(上海)药业有限公司 2024-05-14 — — CN claimed
WO-2023046117-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2023-03-30 — — WO claimed
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2024-11-21 — — US disclosed
EP-4405358-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H Pharmaceuticals Co., Ltd. (CN) 2024-07-31 — — EP disclosed
CN-118043327-A FGFR inhibitors and methods of use thereof 思康睿奇(上海)药业有限公司 2024-05-14 — — CN disclosed
WO-2023046117-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2023-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF FGFR1, FGFR3, FGFR4 CSNK2A2 862/4885CSNK2A1 760/4885BTK 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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