SCHEMBL30326007

SCHEMBL30326007

C=C(F)C(=O)Nc1ccc(-c2nn3ncnc(N)c3c2-c2ccc(C(=O)NC34CC(C(F)(F)F)(C3)C4)c(OC)c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 1/20 0.36
▸ CSNK2A1 P68400 1/20 0.36
▸ TNK2 Q07912 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ THRB P10828 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ BTK Q06187 8/20 0.32
▸ RIPK1 Q13546 4/20 0.32
▸ EGFR P00533 2/20 0.32
▸ TEC P42680 2/20 0.32
▸ TXK P42681 2/20 0.32
▸ BMX P51813 2/20 0.32
▸ LCK P06239 2/20 0.32
▸ TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30326168 0.92 CSNK2A2 (0.35) CSNK2A2CSNK2A1TNK2MAPTTHRB
SCHEMBL31213926 0.90 CSNK2A2 (0.36) CSNK2A2CSNK2A1TNK2MAPTTHRB
SCHEMBL30326052 0.90 TNK2 (0.37) CSNK2A2CSNK2A1TNK2MAPTTHRB
SCHEMBL30325672 0.88 TNK2 (0.36) CSNK2A2CSNK2A1TNK2MAPTTHRB
SCHEMBL30325774 0.87 BTK (0.39) CSNK2A2CSNK2A1MAPTTHRBSMN1; SMN2
SCHEMBL30325706 0.86 CSNK2A2 (0.35) CSNK2A2CSNK2A1TNK2BTKRIPK1
SCHEMBL30325665 0.86 BTK (0.37) CSNK2A2CSNK2A1MAPTTHRBSMN1; SMN2
SCHEMBL30326043 0.86 CSNK2A2 (0.34) CSNK2A2CSNK2A1TNK2BTKRIPK1
SCHEMBL31213887 0.86 BTK (0.36) CSNK2A2CSNK2A1TNK2BTKRIPK1
SCHEMBL30325768 0.86 CSNK2A2 (0.36) CSNK2A2CSNK2A1TNK2MAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2024-11-21 — — US claimed
EP-4405358-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H Pharmaceuticals Co., Ltd. (CN) 2024-07-31 — — EP claimed
WO-2023046117-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2023-03-30 — — WO claimed
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2024-11-21 — — US disclosed
EP-4405358-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H Pharmaceuticals Co., Ltd. (CN) 2024-07-31 — — EP disclosed
WO-2023046117-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF 3H PHARMACEUTICALS CO., LTD. (CN) 2023-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240383905-A1 FGFR INHIBITORS AND METHODS OF USE THEREOF FGFR1, FGFR3, FGFR4 CSNK2A2 862/4885CSNK2A1 760/4885TNK2 493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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