Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 6/20 | 0.36 |
| ▸ | PKLR | P30613 | 6/20 | 0.36 |
| ▸ | PDE1A | P54750 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25164006 | 0.82 | KMT2A (0.39) | PDE9APDE1CPKMPKLRPDE1A | |
| SCHEMBL25165239 | 0.82 | SMN1; SMN2 (0.40) | PDE9APDE1CPDE1APDE1BTP53 | |
| SCHEMBL25163999 | 0.76 | PDE1A (0.54) | PDE9APDE1CPDE1APDE1BHPGD | |
| SCHEMBL25165242 | 0.75 | PDE1A (0.47) | PDE9APDE1CPKMPKLRPDE1A | |
| SCHEMBL21051432 | 0.74 | PDE1C (0.60) | PDE9APDE1CKDM4E | |
| SCHEMBL25164020 | 0.73 | PDE1A (0.36) | PDE9APDE1CPDE1APDE1B | |
| SCHEMBL25875979 | 0.72 | PDE2A (0.35) | PDE9A | |
| SCHEMBL25165145 | 0.72 | MAPT (0.38) | PDE9APDE1CPDE1APDE1BTP53 | |
| SCHEMBL25165156 | 0.70 | PDE1A (0.63) | PDE1CPDE1APDE1BALDH1A1 | |
| SCHEMBL21051515 | 0.64 | PDE1C (0.59) | PDE9APDE1CPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064343-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2023-04-20 | — | — | WO | disclosed |