Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118082 | 0.99 | CRBN (0.66) | CRBNDDB1 | |
| Hydrochloric Acid SCHEMBL30338379 | 0.97 | CRBN (0.64) | CRBNDDB1 | |
| Hydrochloric Acid SCHEMBL30338009 | 0.97 | CRBN (0.64) | CRBNDDB1 | |
| Hydrochloric Acid SCHEMBL30338604 | 0.97 | CRBN (0.64) | CRBNDDB1 | |
| Formic Acid SCHEMBL31071631 | 0.94 | CRBN (0.60) | CRBNDDB1 | |
| SCHEMBL22117962 | 0.87 | DDB1 (0.68) | CRBNDDB1 | |
| SCHEMBL27345838 | 0.86 | CRBN (0.66) | CRBNDDB1 | |
| SCHEMBL31071522 | 0.85 | CRBN (0.62) | CRBNDDB1 | |
| SCHEMBL31071520 | 0.85 | CRBN (0.62) | CRBNDDB1 | |
| SCHEMBL31071533 | 0.85 | CRBN (0.62) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835866-A | Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment | 新基公司 | 2023-03-21 | — | — | CN | disclosed |