SCHEMBL30341111

SCHEMBL30341111

COc1cc(C(=O)Nc2cccc(-c3cccc(NC(=O)OC(C)(C)C)c3C)c2C)ncc1Br

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 20/20 0.60
CD274 Q9NZQ7 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31593225 0.91 PDCD1 (0.71) PDCD1CD274
SCHEMBL22779780 0.91 PDCD1 (0.71) PDCD1CD274
SCHEMBL30341123 0.87 PDCD1 (0.58) PDCD1CD274
SCHEMBL22779869 0.86 PDCD1 (0.69) PDCD1CD274
SCHEMBL28641068 0.86 PDCD1 (0.59) PDCD1CD274
SCHEMBL31108257 0.84 PDCD1 (0.60) PDCD1CD274
SCHEMBL31108263 0.84 PDCD1 (0.57) PDCD1CD274
SCHEMBL18979818 0.83 PDCD1 (0.61) PDCD1CD274
SCHEMBL22675597 0.79 PDCD1 (0.61) PDCD1CD274
SCHEMBL30341115 0.78 PDCD1 (0.61) PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4159720-A1 NONSYMMETRIC SUBSTITUTED 1,1'-BIPHENYL DERIVATIVES AND USES THEREOF Recepton Spolka z Ograniczona Odpowiedzialnoscia (PL) 2023-04-05 EP disclosed