SCHEMBL30346142

SCHEMBL30346142

COCCc1nc2c(N)nc3ccccc3c2n1CCCCNC(=O)c1cnc2ccccc2c1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.58
TLR8 Q9NR97 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL483348 1.00 TLR7 (0.58) TLR7TLR8
SCHEMBL5746945 0.90 TLR7 (0.60) TLR7TLR8
SCHEMBL3865268 0.89 TLR7 (0.66) TLR7TLR8
SCHEMBL14154400 0.87 TLR7 (0.57) TLR7TLR8
SCHEMBL3873131 0.87 TLR7 (0.65) TLR7TLR8
SCHEMBL3863066 0.87 TLR7 (0.60) TLR7
SCHEMBL30345227 0.87 TLR7 (0.58) TLR7TLR8
SCHEMBL483734 0.87 TLR7 (0.58) TLR7TLR8
SCHEMBL13937528 0.87 TLR7 (0.63) TLR7TLR8
SCHEMBL1950333 0.86 TLR7 (0.62) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4419112-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER Ohio State Innovation Foundation (US) 2024-08-28 EP disclosed
CN-118475357-A Immunotherapy for the treatment of cancer 俄亥俄州创新基金会 2024-08-09 CN disclosed
CN-110234401-B Methods and compositions for adaptive immunomodulation 德克萨斯大学系统董事会 2024-03-01 CN disclosed
US-20240033348-A1 METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION Pulmotect, Inc. 2024-02-01 US disclosed
WO-2023070132-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER OHIO STATE INNOVATION FOUNDATION (US) 2023-04-27 WO disclosed