Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | CLK2 | P49760 | 3/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 3/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25522524 | 1.00 | DYRK1A (0.39) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL30346895 | 0.91 | DYRK1A (0.40) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL25522523 | 0.91 | DYRK1A (0.40) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL25522522 | 0.91 | DYRK1A (0.40) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL30349099 | 0.88 | BRD4 (0.40) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL25522648 | 0.88 | BRD4 (0.40) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL25522509 | 0.85 | DYRK1A (0.41) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL30348780 | 0.85 | DYRK1A (0.41) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL25522508 | 0.85 | DYRK1A (0.41) | DYRK1ACLK2CLK3BRD4DYRK1B | |
| SCHEMBL30347828 | 0.84 | DYRK1A (0.39) | DYRK1ACLK2CLK3BRD4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |