Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.65 |
| ▸ | CLK2 | P49760 | 2/20 | 0.65 |
| ▸ | CLK3 | P49761 | 2/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 4/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25158769 | 1.00 | DYRK1A (0.65) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25201523 | 0.89 | DYRK1A (0.55) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL30349412 | 0.89 | DYRK1A (0.55) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25158041 | 0.89 | DYRK1A (0.55) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25157324 | 0.88 | DYRK1A (0.54) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL30346585 | 0.87 | DYRK1A (0.49) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25211955 | 0.87 | DYRK1A (0.49) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25157453 | 0.87 | DYRK1A (0.55) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL25157421 | 0.87 | DYRK1A (0.53) | DYRK1ACLK2CLK3DYRK1BRET | |
| SCHEMBL30349016 | 0.87 | DYRK1A (0.55) | DYRK1ACLK2CLK3DYRK1BRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2023-06-01 | — | — | US | claimed |
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | DYRK1A 1/4885CLK2 466/4885CLK3 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.