Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 15/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 10/20 | 0.39 |
| ▸ | SYK | P43405 | 10/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123524 | 0.90 | TTK (0.37) | ZAP70KARS1SYKMAPKAPK5 | |
| Hydrochloric Acid SCHEMBL30385412 | 0.90 | TTK (0.37) | ZAP70KARS1SYKMAPKAPK5 | |
| Hydrochloric Acid SCHEMBL22123495 | 0.90 | TTK (0.37) | ZAP70KARS1SYKMAPKAPK5 | |
| Formic Acid SCHEMBL30171996 | 0.88 | ZAP70 (0.39) | ZAP70KARS1SYK | |
| SCHEMBL30171910 | 0.87 | BRD4 (0.36) | ZAP70KARS1SYKMAPKAPK5 | |
| Formic Acid SCHEMBL22123789 | 0.87 | PDE10A (0.34) | ZAP70KARS1SYK | |
| SCHEMBL22123380 | 0.86 | ZAP70 (0.39) | ZAP70KARS1SYK | |
| SCHEMBL30171548 | 0.86 | ZAP70 (0.39) | ZAP70KARS1SYK | |
| Formic Acid SCHEMBL30171987 | 0.86 | ALK (0.38) | ZAP70KARS1SYKMAP4K4MAP4K2 | |
| SCHEMBL22122949 | 0.85 | ZAP70 (0.40) | ZAP70KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | ZAP70 716/4885KARS1 610/4885SYK 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.