SCHEMBL30352199 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	CRBN	Q96SW2	15/20	0.55

▸	DDB1	Q16531	6/20	0.43

▸	IKZF3	Q9UKT9	3/20	0.40

▸	BRD4	O60885	1/20	0.40

▸	TNF	P01375	1/20	0.40

▸	IL1B	P01584	1/20	0.40

▸	IKZF1	Q13422	1/20	0.40

▸	CXCR4	P61073	2/20	0.37

▸	ALDH1A1	P00352	1/20	0.37

▸	CHRM2	P08172	1/20	0.37

▸	OPRM1	P35372	1/20	0.37

▸	CYP1A2	P05177	1/20	0.37

▸	TSHR	P16473	1/20	0.37

▸	TDP1	Q9NUW8	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30351735	0.92	CRBN (0.55)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30352048	0.87	CRBN (0.49)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30352214	0.85	CRBN (0.46)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30352133	0.85	CRBN (0.46)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30352051	0.83	CRBN (0.49)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30459121	0.82	CRBN (0.53)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30352251	0.82	CRBN (0.49)	CRBNDDB1
SCHEMBL26091781	0.82	CRBN (0.61)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL31034013	0.82	CRBN (0.61)	CRBNDDB1IKZF3BRD4TNF
SCHEMBL30351703	0.81	CRBN (0.60)	CRBNDDB1IKZF3BRD4TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023066350-A1	CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS	标新生物医药科技(上海)有限公司	2023-04-27	—	—	WO	claimed