Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 6/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353531 | 1.00 | PRKDC (0.44) | PRKDCPIK3CAPIK3CDP2RY12PIK3CB | |
| SCHEMBL25618870 | 1.00 | PRKDC (0.44) | PRKDCPIK3CAPIK3CDP2RY12PIK3CB | |
| SCHEMBL25270177 | 0.77 | PIK3CD (0.44) | PRKDCPIK3CAPIK3CDP2RY12PIK3CB | |
| SCHEMBL30353528 | 0.77 | PIK3CD (0.44) | PRKDCPIK3CAPIK3CDP2RY12PIK3CB | |
| SCHEMBL25617735 | 0.76 | PIK3CA (0.63) | PRKDCPIK3CAPIK3R1 | |
| SCHEMBL31547941 | 0.76 | PIK3CA (0.63) | PRKDCPIK3CAPIK3R1 | |
| SCHEMBL31547982 | 0.75 | PIK3CA (0.57) | PIK3CAPIK3R1ALDH1A1MAPK1 | |
| SCHEMBL24099574 | 0.75 | PIK3CA (0.57) | PIK3CAPIK3R1ALDH1A1MAPK1 | |
| SCHEMBL30353544 | 0.74 | PIK3CA (0.54) | PIK3CAPIK3R1CSNK1D | |
| SCHEMBL25617472 | 0.74 | PIK3CA (0.54) | PIK3CAPIK3R1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444317-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107623-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
| EP-4161523-A1 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Yumanity Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |