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SCHEMBL30355172

SCHEMBL30355172

COc1cc(C(C)C(=O)N2CCC3(CCc4cc(-c5ncccn5)c(C)nc4N3)C2)c(Cl)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 20/20 1.00
▸ KCNH2 Q12809 2/20 0.66
▸ MC5R P33032 1/20 0.66
▸ MC3R P41968 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25267222 1.00 MC4R (1.00) MC4RKCNH2MC5RMC3R
SCHEMBL25583997 1.00 MC4R (1.00) MC4RKCNH2MC5RMC3R
SCHEMBL30184858 1.00 MC4R (1.00) MC4RKCNH2MC5RMC3R
SCHEMBL24094569 1.00 MC4R (1.00) MC4RKCNH2MC5RMC3R
SCHEMBL25587564 0.96 MC4R (0.92) MC4RKCNH2MC5RMC3R
SCHEMBL24094549 0.92 MC4R (0.86) MC4RKCNH2MC5RMC3R
SCHEMBL24094548 0.92 MC4R (0.86) MC4RKCNH2MC5RMC3R
SCHEMBL31139161 0.92 MC4R (0.86) MC4RKCNH2MC5RMC3R
SCHEMBL31139155 0.92 MC4R (1.00) MC4RKCNH2MC5RMC3R
SCHEMBL24094602 0.92 MC4R (1.00) MC4RKCNH2MC5RMC3R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4161927-B9 SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF PFIZER (US) 2024-11-06 — — EP disclosed
EP-4161927-B1 SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF PFIZER (US) 2024-08-07 — — EP disclosed
EP-4161927-A1 SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF Pfizer Inc. (US) 2023-04-12 — — EP disclosed
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