Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20918792 | 1.00 | JAK1 (0.55) | JAK1JAK2JAK3GSK3BMAPK14 | |
| SCHEMBL20919114 | 0.89 | JAK2 (0.46) | JAK1JAK2JAK3GSK3BMAPK14 | |
| SCHEMBL30356176 | 0.89 | JAK2 (0.46) | JAK1JAK2JAK3GSK3BMAPK14 | |
| SCHEMBL20918093 | 0.84 | JAK1 (0.77) | JAK1 | |
| SCHEMBL20930670 | 0.78 | JAK1 (0.51) | JAK1 | |
| SCHEMBL30356056 | 0.78 | JAK1 (0.71) | JAK1 | |
| SCHEMBL20918015 | 0.78 | JAK1 (0.71) | JAK1 | |
| SCHEMBL20918453 | 0.75 | JAK1 (0.48) | JAK1JAK2JAK3 | |
| SCHEMBL20918455 | 0.75 | JAK1 (0.56) | JAK1JAK2JAK3 | |
| SCHEMBL20917871 | 0.75 | JAK1 (0.60) | JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111372931-B | Heterocyclic compounds as protein kinase inhibitors | 怡诺安有限公司 | 2023-03-24 | — | — | CN | disclosed |