Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 15/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.41 |
| ▸ | PIM1 | P11309 | 7/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.41 |
| ▸ | CLK1 | P49759 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26106241 | 1.00 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30363449 | 1.00 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL26106475 | 1.00 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30363419 | 0.88 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL26107735 | 0.88 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30363405 | 0.88 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL26105529 | 0.88 | DYRK2 (0.42) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30494051 | 0.85 | DYRK2 (0.49) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30494253 | 0.85 | DYRK2 (0.49) | DYRK2CDK5CDK5R1DYRK1ADYRK1B | |
| SCHEMBL30494290 | 0.85 | DYRK2 (0.49) | DYRK2CDK5CDK5R1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422747-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | claimed |
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| EP-4422747-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |