Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.50 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23902638 | 1.00 | EGFR (0.51) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL23902630 | 0.89 | EGFR (0.58) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL30364662 | 0.89 | EGFR (0.58) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL30241481 | 0.85 | ERBB2 (0.60) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL23902645 | 0.85 | ERBB2 (0.60) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL23902641 | 0.83 | ERBB2 (0.59) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL30241337 | 0.83 | FGFR1 (0.58) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL26099975 | 0.83 | FGFR1 (0.58) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL26101571 | 0.83 | EGFR (0.61) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL23902662 | 0.83 | KCNQ3 (0.53) | EGFRKCNQ3KCNQ2KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | claimed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | claimed |
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | disclosed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | disclosed |