Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 6/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435901 | 0.91 | PTPN11 (0.46) | PTPN11NTRK1CSF1RNTRK2KCNH2 | |
| SCHEMBL31435962 | 0.91 | NTRK1 (0.47) | PTPN11NTRK1CSF1RNTRK2KCNH2 | |
| SCHEMBL31436004 | 0.89 | PTPN11 (0.49) | PTPN11PIK3CANTRK1CSF1RNTRK2 | |
| SCHEMBL31435998 | 0.88 | PTPN11 (0.46) | PTPN11PIK3CANTRK1CSF1RNTRK2 | |
| SCHEMBL30280376 | 0.82 | PTPN11 (0.50) | PTPN11PIK3CAKCNH2 | |
| SCHEMBL30280389 | 0.81 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL31435919 | 0.80 | PTPN11 (0.43) | PTPN11PIK3CANTRK1CSF1RNTRK2 | |
| SCHEMBL31435963 | 0.80 | PTPN11 (0.43) | PTPN11PIK3CAKCNH2MTORRET | |
| SCHEMBL30365695 | 0.80 | PTPN11 (0.45) | PTPN11PIK3CAKCNH2MTORRET | |
| SCHEMBL31435954 | 0.79 | PTPN11 (0.43) | PTPN11PIK3CANTRK1CSF1RNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023049270-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES AS TYRO3 INHIBITORS | Halia Therapeutics, Inc. (US) | 2023-03-30 | — | — | WO | disclosed |