Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | PKM | P14618 | 1/20 | 0.80 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PLG | P00747 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.50 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.50 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.50 |
| ▸ | FPR3 | P25089 | 1/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | GNRHR | P30968 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26131403 | 0.89 | KDM4E (1.00) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL15661860 | 0.88 | KDM4E (0.80) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL13947430 | 0.88 | KDM4E (0.80) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL3126505 | 0.87 | KDM4E (0.79) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL20615646 | 0.87 | KDM4E (0.79) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL20615733 | 0.87 | KDM4E (0.79) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL16825871 | 0.87 | KDM4E (0.79) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL557627 | 0.84 | KDM4E (0.73) | KDM4EPKMGPR119KMT2AF2 | |
| SCHEMBL26668533 | 0.81 | KDM4E (0.70) | KDM4EPKMGPR119KMT2AMEN1 | |
| SCHEMBL21586161 | 0.81 | KDM4E (0.76) | KDM4EPKMGPR119KMT2AFPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA (SE) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | KDM4E 2452/4885PKM 1101/4885GPR119 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.