Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30366230 | 1.00 | MEN1 (0.46) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL23062504 | 0.92 | MEN1 (0.46) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL30366151 | 0.88 | MEN1 (0.45) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL30899631 | 0.88 | MEN1 (0.45) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL30366333 | 0.84 | PDE4B (0.43) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL30899632 | 0.84 | PDE4B (0.43) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL529304 | 0.83 | TACR1 (0.51) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL23982322 | 0.83 | TACR1 (0.51) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL18741911 | 0.83 | MEN1 (0.52) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL30294196 | 0.83 | MEN1 (0.52) | MEN1KMT2AUSP2HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405051-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| CN-118076604-A | Pyrazolo [3,4-b ] pyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023046806-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |