Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.59 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | STK4 | Q13043 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16011508 | 0.80 | SIRT2 (0.75) | SIRT2SIRT1SIRT3 | |
| SCHEMBL16011667 | 0.77 | SIRT2 (0.86) | SIRT2SIRT1SIRT3 | |
| SCHEMBL16014075 | 0.75 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL30271533 | 0.73 | SIRT2 (0.76) | SIRT2SIRT1SIRT3PIK3CA | |
| SCHEMBL16011606 | 0.72 | SIRT2 (0.44) | SIRT2SIRT1SIRT3AURKARPS6KB1 | |
| SCHEMBL20841614 | 0.71 | MAPK1 (0.64) | MAPK1PIK3CACHRM4KDM4EALDH1A1 | |
| SCHEMBL20841483 | 0.69 | PIK3CA (0.65) | MAPK1PIK3CACHRM4KDM4EALDH1A1 | |
| SCHEMBL20841613 | 0.69 | CHRM4 (0.80) | MAPK1PIK3CACHRM4KDM4EALDH1A1 | |
| SCHEMBL20841615 | 0.68 | MAPK1 (1.00) | MAPK1AURKARPS6KB1PIK3CAIKBKB | |
| SCHEMBL21048259 | 0.68 | MAPK1 (0.71) | MAPK1PIK3CACHRM4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4165045-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | Monash University (AU) | 2023-04-19 | — | — | EP | claimed |
| EP-4165045-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | Monash University (AU) | 2023-04-19 | — | — | EP | disclosed |