Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.59 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.59 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1825815 | 1.00 | NOTUM (0.71) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL30366447 | 1.00 | NOTUM (0.71) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL17018045 | 1.00 | NOTUM (0.71) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL20462833 | 0.87 | TSHR (0.62) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL7785444 | 0.85 | TSHR (0.60) | NOTUMTSHRPDK1PDK2PDK3 | |
| Lithium Ion SCHEMBL22092468 | 0.84 | TSHR (0.59) | NOTUMTSHRPDK1PDK2PDK3 | |
| Lithium Ion SCHEMBL30437889 | 0.84 | TSHR (0.59) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL24953447 | 0.83 | POLB (0.56) | NOTUMTSHRPDK1PDK2PDK3 | |
| SCHEMBL2586534 | 0.83 | NOTUM (1.00) | NOTUMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10167044 | 0.83 | NOTUM (1.00) | NOTUMMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4165045-A1 | DUAL KINASE-BROMODOMAIN INHIBITORS | Monash University (AU) | 2023-04-19 | — | — | EP | disclosed |