Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 1.00 |
| ▸ | EPM2A | O95278 | 1/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.72 |
| ▸ | PTPRG | P23470 | 1/20 | 0.72 |
| ▸ | ACP1 | P24666 | 1/20 | 0.72 |
| ▸ | PTPN3 | P26045 | 1/20 | 0.72 |
| ▸ | PTPRM | P28827 | 1/20 | 0.72 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.72 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.72 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.72 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.72 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.72 |
| ▸ | PTPN14 | Q15678 | 1/20 | 0.72 |
| ▸ | PTPN21 | Q16825 | 1/20 | 0.72 |
| ▸ | UBLCP1 | Q8WVY7 | 1/20 | 0.72 |
| ▸ | DUSP23 | Q9BVJ7 | 1/20 | 0.72 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.72 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.72 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.72 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16375404 | 1.00 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL16376122 | 0.92 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL16376231 | 0.91 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL17669825 | 0.91 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL16375397 | 0.90 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL30367054 | 0.90 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL18323102 | 0.90 | PTPN11 (0.85) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL16375402 | 0.90 | PTPN11 (1.00) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL18323107 | 0.90 | PTPN11 (0.81) | PTPN11EPM2APTPN1PTPRGACP1 | |
| SCHEMBL18323112 | 0.90 | PTPN11 (0.81) | PTPN11EPM2APTPN1PTPRGACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | disclosed |