Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BRD1 | O95696 | 2/20 | 0.31 |
| ▸ | TAF1 | P21675 | 2/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30367868 | 0.84 | MAPK13 (0.35) | CYP1B1KMT2AMEN1RAB9AMAPK1 | |
| SCHEMBL30367512 | 0.70 | MAPK1 (0.38) | KMT2AMEN1MAPK1GSK3B | |
| SCHEMBL31052465 | 0.69 | KDM4E (0.40) | KMT2AMEN1GAAMAPK1 | |
| SCHEMBL419865 | 0.68 | KDR (0.35) | NR1H2NR1H3KMT2AMEN1RAB9A | |
| SCHEMBL10112088 | 0.65 | DNMT1 (0.40) | NR1H2NR1H3KMT2AMEN1GAA | |
| SCHEMBL31439960 | 0.65 | MEN1 (0.38) | NR1H2NR1H3KMT2AMEN1GAA | |
| SCHEMBL423584 | 0.64 | KDR (0.41) | KMT2AMEN1 | |
| SCHEMBL420191 | 0.63 | NR1H3 (0.40) | NR1H3KMT2AMEN1GAAMAPK1 | |
| SCHEMBL21114112 | 0.62 | ADORA2A (0.43) | NR1H2NR1H3GAAADORA2AADORA2B | |
| SCHEMBL30274181 | 0.62 | ADORA2A (0.43) | NR1H2NR1H3GAAADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023155886-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-08-24 | — | — | WO | disclosed |
| CN-116437918-A | Pyrazolopyridine compounds as TAM inhibitors | 上海德琪医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2023051464-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-04-06 | — | — | WO | disclosed |