Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.60 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 5/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19474462 | 1.00 | EHMT2 (0.60) | EHMT2EHMT1IGF1RBRD4AXL | |
| SCHEMBL19476678 | 0.93 | EHMT2 (0.61) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19477048 | 0.91 | EHMT2 (0.60) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19476335 | 0.91 | EHMT2 (0.60) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19462412 | 0.90 | EHMT2 (0.59) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19476739 | 0.90 | EHMT2 (0.59) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19700638 | 0.89 | EHMT2 (0.56) | EHMT2EHMT1IGF1RBRD4AXL | |
| SCHEMBL25622668 | 0.89 | EHMT2 (0.77) | EHMT2EHMT1IGF1RBRD4KDM4E | |
| SCHEMBL19474425 | 0.88 | EHMT2 (0.56) | EHMT2EHMT1IGF1RBRD4SRC | |
| SCHEMBL19461925 | 0.88 | EHMT2 (0.56) | EHMT2EHMT1IGF1RBRD4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |