Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 12/20 | 0.63 |
| ▸ | EHMT1 | Q9H9B1 | 7/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | SPIN1 | Q9Y657 | 4/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19476604 | 1.00 | EHMT2 (0.63) | EHMT2EHMT1SRCDNMT1IGF1R | |
| SCHEMBL19476600 | 0.92 | EHMT2 (0.58) | EHMT2EHMT1SRCDNMT1IGF1R | |
| SCHEMBL19476651 | 0.88 | EHMT2 (0.74) | EHMT2EHMT1SRCDNMT1IGF1R | |
| SCHEMBL19462428 | 0.86 | EHMT2 (0.57) | EHMT2EHMT1SRCDNMT1SPIN1 | |
| SCHEMBL19474456 | 0.85 | EHMT2 (0.52) | EHMT2EHMT1SRCIGF1RSPIN1 | |
| SCHEMBL30367539 | 0.85 | EHMT2 (0.52) | EHMT2EHMT1SRCIGF1RSPIN1 | |
| SCHEMBL19476329 | 0.85 | EHMT2 (0.56) | EHMT2EHMT1SRCIGF1RSPIN1 | |
| SCHEMBL19476599 | 0.84 | EHMT2 (0.66) | EHMT2EHMT1SRCDNMT1IGF1R | |
| SCHEMBL30367411 | 0.84 | EHMT2 (0.66) | EHMT2EHMT1SRCDNMT1IGF1R | |
| SCHEMBL19462243 | 0.82 | EHMT2 (0.52) | EHMT2EHMT1SRCSPIN1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |