Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19476705 | 1.00 | EGFR (0.48) | EGFRIGF1RAURKADOT1LAIMP2 | |
| SCHEMBL25612681 | 0.87 | EGFR (0.44) | EGFRIGF1RAURKADOT1LAIMP2 | |
| SCHEMBL19476605 | 0.82 | IGF1R (0.58) | EGFRIGF1RAIMP2KDRINSR | |
| SCHEMBL30367379 | 0.81 | EGFR (0.48) | EGFRIGF1RDOT1LAIMP2KDR | |
| SCHEMBL19477506 | 0.81 | EGFR (0.48) | EGFRIGF1RDOT1LAIMP2KDR | |
| SCHEMBL19700631 | 0.79 | SMN1; SMN2 (0.57) | EGFRCDK2SYK | |
| SCHEMBL21743299 | 0.79 | SMN1; SMN2 (0.57) | EGFRCDK2SYK | |
| SCHEMBL19700632 | 0.79 | SMN1; SMN2 (0.57) | EGFRCDK2SYK | |
| SCHEMBL19476675 | 0.73 | HRH3 (0.52) | EGFRIGF1RAIMP2KDRINSR | |
| SCHEMBL30367474 | 0.71 | HRH3 (0.46) | EGFRIGF1RAURKAAIMP2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |