Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | BCR | P11274 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | STK25 | O00506 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CASK | O14936 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265051 | 1.00 | SRC (0.52) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL12320573 | 0.94 | SRC (0.52) | SRCABL1BCRSYKALK | |
| SCHEMBL264711 | 0.91 | SRC (0.54) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL263862 | 0.89 | BRD4 (0.56) | SRCABL1BCREGFRFYN | |
| SCHEMBL269990 | 0.86 | SYK (0.48) | SRCABL1BCREGFRFYN | |
| SCHEMBL12320602 | 0.85 | SRC (0.54) | SRCABL1BCREGFRJAK2 | |
| SCHEMBL12320601 | 0.84 | BRD4 (0.54) | SRCABL1BCREGFRFYN | |
| SCHEMBL271265 | 0.81 | BRD4 (0.59) | SRCABL1BCREGFRFYN | |
| SCHEMBL5469368 | 0.79 | PRKCQ (0.65) | SRCABL1BCRLCKPRKCE | |
| SCHEMBL263867 | 0.78 | PRKCQ (0.51) | SRCEGFRSYKJAK2YES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118021814-A | Combination therapy with EHMT2 inhibitors | EPIZYME股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-110621316-B | Combination therapy with EHMT2 inhibitors | EPIZYME股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |