⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30368340 | 0.83 | KDM1A (0.31) | — | |
| SCHEMBL26083473 | 0.83 | KDM1A (0.31) | — | |
| SCHEMBL29809756 | 0.82 | BTK (0.31) | — | |
| SCHEMBL26083481 | 0.82 | BTK (0.31) | — | |
| SCHEMBL27214149 | 0.81 | — | — | |
| SCHEMBL26083471 | 0.78 | NPC1 (0.31) | — | |
| SCHEMBL24165176 | 0.70 | KDM1A (0.32) | — | |
| SCHEMBL30368735 | 0.70 | KDM1A (0.32) | — | |
| SCHEMBL24165215 | 0.69 | BTK (0.34) | — | |
| SCHEMBL30368541 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175719-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2023-05-10 | — | — | EP | disclosed |