Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | DDO | Q99489 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.34 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24165242 | 1.00 | DAO (0.37) | DAODDOCHUKTSHRMAPK1 | |
| SCHEMBL25475044 | 0.84 | DAO (0.35) | DAODDOCHUKTSHRPIN1 | |
| SCHEMBL29486783 | 0.74 | PRKCI (0.54) | PIN1TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL1935167 | 0.74 | PRKCI (0.54) | PIN1TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL26326481 | 0.74 | AURKB (0.46) | — | |
| SCHEMBL2250758 | 0.68 | TSHR (0.47) | CHUKTSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL29742161 | 0.68 | TSHR (0.47) | CHUKTSHRMAPK1VCAM1MAPT | |
| SCHEMBL405386 | 0.68 | TSHR (0.47) | CHUKTSHRMAPK1VCAM1MAPT | |
| SCHEMBL202663 | 0.67 | POLB (0.51) | TSHRMAPK1PIN1TDP1ALDH1A1 | |
| SCHEMBL29381779 | 0.67 | POLB (0.51) | TSHRMAPK1PIN1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175719-A1 | TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS | Incyte Corporation (US) | 2023-05-10 | — | — | EP | disclosed |