Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 7/20 | 1.00 |
| ▸ | GSK3B | P49841 | 9/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.64 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.64 |
| ▸ | CDK1 | P06493 | 3/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.64 |
| ▸ | PRKACA | P17612 | 3/20 | 0.64 |
| ▸ | PRKACG | P22612 | 3/20 | 0.64 |
| ▸ | PRKACB | P22694 | 3/20 | 0.64 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.64 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.64 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.64 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.64 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.59 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982761 | 1.00 | CLK1 (1.00) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL30369770 | 0.90 | CLK1 (0.82) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL28982792 | 0.90 | CLK1 (0.82) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL2239305 | 0.80 | CLK1 (0.66) | CLK1GSK3BCDK5CDK5R1PDPK1 | |
| Meridianin D SCHEMBL23539138 | 0.78 | GSK3B (1.00) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| Meridianin D SCHEMBL31094009 | 0.78 | GSK3B (1.00) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL29488164 | 0.78 | GSK3B (0.71) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL23175317 | 0.78 | GSK3B (0.71) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL30369123 | 0.78 | GSK3B (1.00) | CLK1GSK3BCDK5CDK5R1DYRK1A | |
| SCHEMBL28492625 | 0.78 | MAP3K14 (0.80) | CLK1GSK3BCDK5CDK5R1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115925686-B | MERIDIANIN derivatives, lewis acid-promoted coupling synthesis method and application thereof | 贵州医科大学 | 2024-07-30 | — | — | CN | disclosed |
| CN-115925686-A | Meridianin derivatives, coupling synthesis method and application thereof promoted by Lewis acid | 贵州医科大学 | 2023-04-07 | — | — | CN | disclosed |