SCHEMBL30374359

SCHEMBL30374359

Cn1cnnc1C(c1cccc(N2Cc3c(cc(CNC4(C)CCC4)cc3C(F)(F)F)C2=O)c1)N1CCC1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CBLB Q13191 20/20 0.70
CBLC Q9ULV8 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25173609 1.00 CBLB (0.70) CBLBCBLC
SCHEMBL25179663 1.00 CBLB (0.70) CBLBCBLC
SCHEMBL30373924 1.00 CBLB (0.70) CBLBCBLC
SCHEMBL25173608 1.00 CBLB (0.70) CBLBCBLC
SCHEMBL30374741 1.00 CBLB (0.70) CBLBCBLC
SCHEMBL25179658 0.93 CBLB (0.71) CBLBCBLC
SCHEMBL30374466 0.93 CBLB (0.71) CBLBCBLC
SCHEMBL25314175 0.93 CBLB (0.71) CBLBCBLC
SCHEMBL25179657 0.93 CBLB (0.71) CBLBCBLC
SCHEMBL30483644 0.93 CBLB (0.71) CBLBCBLC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4426691-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL Genentech, Inc. (US) 2024-09-11 EP disclosed
WO-2023081853-A1 LACTAMS AS CBL-B INHIBITORS SELECTIVE OVER C-CBL GENENTECH, INC. (US) 2023-05-11 WO disclosed