Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20680053 | 1.00 | DYRK1A (0.52) | DYRK1AGSK3BRPS6KA5PDE4BCDK4 | |
| SCHEMBL17141093 | 0.90 | MAP3K14 (0.52) | DYRK1ARPS6KA5PDE4BCLK1MAPT | |
| SCHEMBL19532565 | 0.89 | DYRK1A (0.51) | DYRK1AGSK3BPDE4BCDK4CCND1 | |
| SCHEMBL30261038 | 0.85 | GSK3B (0.47) | DYRK1AGSK3BPDE4BCDK4CCND1 | |
| SCHEMBL17683297 | 0.85 | GSK3B (0.47) | DYRK1AGSK3BPDE4BCDK4CCND1 | |
| SCHEMBL20680088 | 0.83 | RPS6KA5 (0.53) | RPS6KA5CLK1MAP3K14MEN1KMT2A | |
| SCHEMBL30554773 | 0.83 | RPS6KA5 (0.53) | RPS6KA5CLK1MAP3K14MEN1KMT2A | |
| SCHEMBL21629016 | 0.83 | RPS6KA5 (0.56) | DYRK1AGSK3BRPS6KA5CLK1MAP3K14 | |
| SCHEMBL30554764 | 0.83 | RPS6KA5 (0.56) | DYRK1AGSK3BRPS6KA5CLK1MAP3K14 | |
| SCHEMBL29990756 | 0.82 | DYRK1A (0.50) | DYRK1AGSK3BPDE4BCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102575-B | Cyclic 2-aminopyrimidine compound and application thereof | 暨南大学 | 2025-01-17 | — | — | CN | disclosed |
| CN-116102575-A | Cyclic 2-aminopyrimidine compound and application thereof | 暨南大学 | 2023-05-12 | — | — | CN | disclosed |