SCHEMBL30376331

SCHEMBL30376331

CNC(=O)c1ccc2c(c1)OC(F)(F)O2

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMYD3 Q9H7B4 5/20 0.57
CTNNB1 P35222 3/20 0.54
WNT3A P56704 3/20 0.54
TAS2R8 Q9NYW2 1/20 0.44
HDAC8 Q9BY41 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC2 Q92769 1/20 0.43
ROCK2 O75116 1/20 0.42
THRB P10828 1/20 0.42
DHODH Q02127 1/20 0.42
PLAU P00749 1/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26208395 0.85 SMN1; SMN2 (0.47) SMYD3HDAC8HDAC6HDAC2PLAU
SCHEMBL20166666 0.83 SMYD3 (0.60) SMYD3CTNNB1WNT3ATAS2R8ROCK2
SCHEMBL22902082 0.83 SMYD3 (0.53) SMYD3CTNNB1WNT3ATAS2R8DHODH
SCHEMBL1347343 0.81 CTNNB1 (0.58) SMYD3CTNNB1WNT3ATAS2R8
SCHEMBL10407674 0.80 CTNNB1 (0.61) SMYD3CTNNB1WNT3A
SCHEMBL1012928 0.80 CTNNB1 (0.54) SMYD3CTNNB1WNT3AMEN1LMNA
Bromide SCHEMBL31218174 0.79 KIT (0.44) SMYD3CTNNB1WNT3ATAS2R8MEN1
SCHEMBL351400 0.79 CTNNB1 (0.64) SMYD3CTNNB1WNT3AGAA
SCHEMBL3866171 0.79 CTNNB1 (0.59) SMYD3CTNNB1WNT3ATAS2R8ROCK2
SCHEMBL31070402 0.78 HTR1B (0.52) SMYD3CTNNB1WNT3ATAS2R8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023051261-A1 IMINE COMPOUND AND USE THEREOF 沈阳中化农药化工研发有限公司 2023-04-06 WO disclosed