Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25289146 | 1.00 | TEAD1 (0.41) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL25749393 | 0.86 | TEAD1 (0.41) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL25293802 | 0.85 | TEAD1 (0.43) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL25245411 | 0.84 | ALOX5AP (0.44) | SCN5ASCN9ASCN2AGAACTSD | |
| SCHEMBL31135913 | 0.84 | ALOX5AP (0.44) | SCN5ASCN9ASCN2AGAACTSD | |
| SCHEMBL25250532 | 0.81 | FNTB (0.47) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL30377191 | 0.81 | FNTB (0.47) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL30377004 | 0.81 | KDM5A (0.53) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL25247701 | 0.81 | KDM5A (0.53) | TEAD1TEAD4TEAD2TEAD3SCN5A | |
| SCHEMBL25251475 | 0.80 | TEAD1 (0.48) | TEAD1TEAD4TEAD2TEAD3SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436969-A2 | BICYCLIC THERAPEUTIC COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118451077-A | Bicyclic therapeutic compounds and methods for treatment of cancer | 基因泰克公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023097194-A2 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |