Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.57 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.57 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.57 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.57 |
| ▸ | CHKA known ✓ | P35790 | 2/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.44 |
| ▸ | CHAT | P28329 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30379330 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379267 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379542 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379369 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379273 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379537 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379194 | 1.00 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL12533267 | 0.99 | CHRM2 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL30379896 | 0.99 | CHRM2 (0.58) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL26093619 | 0.99 | CHRM2 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419206-B1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA (ES) | 2025-09-17 | — | — | EP | claimed |
| US-20240415825-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundación Privada Instituto De Salud Global Barcelona (ES) | 2024-12-19 | — | — | US | claimed |
| EP-4419206-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundacio Institut de Bioenginyeria de Catalunya (ES) | 2024-08-28 | — | — | EP | claimed |
| CN-118475559-A | Compounds for malaria treatment | 加泰罗尼亚生物工程基金会研究所 | 2024-08-09 | — | — | CN | claimed |
| WO-2023067170-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (ES) | 2023-04-27 | — | — | WO | claimed |
| EP-4419206-B1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA (ES) | 2025-09-17 | — | — | EP | disclosed |
| US-20240415825-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundación Privada Instituto De Salud Global Barcelona (ES) | 2024-12-19 | — | — | US | disclosed |
| EP-4419206-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundacio Institut de Bioenginyeria de Catalunya (ES) | 2024-08-28 | — | — | EP | disclosed |
| CN-118475559-A | Compounds for malaria treatment | 加泰罗尼亚生物工程基金会研究所 | 2024-08-09 | — | — | CN | disclosed |
| WO-2023067170-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (ES) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240415825-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | ABAT, GLS2, CPS1 | CHRM2 2286/4885CHRM4 3290/4885CHRM5 2321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.