Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.79 |
| ▸ | JAK1 | P23458 | 13/20 | 0.79 |
| ▸ | JAK2 | O60674 | 7/20 | 0.79 |
| ▸ | BRD4 | O60885 | 7/20 | 0.79 |
| ▸ | RET | P07949 | 4/20 | 0.79 |
| ▸ | TYK2 | P29597 | 4/20 | 0.79 |
| ▸ | FLT3 | P36888 | 4/20 | 0.79 |
| ▸ | BTK | Q06187 | 4/20 | 0.79 |
| ▸ | SYK | P43405 | 4/20 | 0.79 |
| ▸ | EGFR | P00533 | 3/20 | 0.79 |
| ▸ | PLK4 | O00444 | 3/20 | 0.79 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.79 |
| ▸ | AURKA | O14965 | 3/20 | 0.79 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.79 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.79 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.79 |
| ▸ | PAK4 | O96013 | 3/20 | 0.79 |
| ▸ | ABL1 | P00519 | 3/20 | 0.79 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.79 |
| ▸ | INSR | P06213 | 3/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264158 | 1.00 | JAK3 (0.79) | JAK3JAK1JAK2BRD4RET | |
| SCHEMBL28489539 | 0.92 | BRD4 (0.81) | JAK3JAK1JAK2BRD4RET | |
| SCHEMBL20285974 | 0.92 | JAK2 (0.81) | JAK3JAK1JAK2BRD4RET | |
| SCHEMBL20330039 | 0.92 | BRD4 (0.82) | JAK3JAK1JAK2BRD4RET | |
| SCHEMBL16985210 | 0.91 | BRD4 (0.84) | JAK3JAK1JAK2BRD4RET | |
| Fedratinib SCHEMBL29351417 | 0.89 | BRD4 (1.00) | JAK3JAK1JAK2BRD4RET | |
| Fedratinib SCHEMBL263741 | 0.89 | BRD4 (1.00) | JAK3JAK1JAK2BRD4RET | |
| SCHEMBL13868200 | 0.88 | BRD4 (0.79) | JAK3JAK1JAK2BRD4RET | |
| Fedratinib SCHEMBL2734027 | 0.88 | BRD4 (0.98) | JAK3JAK1JAK2BRD4RET | |
| Fedratinib SCHEMBL21773035 | 0.87 | BRD4 (0.91) | JAK3JAK1JAK2BRD4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163437-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-116490507-A | Heterocyclic condensation CDC7 kinase inhibitors for the treatment of cancer | 薛定谔公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-111630054-B | Substituted pyrazolo [3,4-d ] pyrimidine compounds as RET kinase inhibitors | 奥瑞生物药品公司 | 2023-05-09 | — | — | CN | disclosed |