Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 1.00 |
| ▸ | WDR77 | Q9BQA1 | 18/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391701 | 1.00 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL18026294 | 1.00 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL21413929 | 1.00 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL29806232 | 1.00 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL18026039 | 0.92 | PRMT5 (0.85) | PRMT5WDR77 | |
| SCHEMBL18026086 | 0.92 | PRMT5 (0.85) | PRMT5WDR77 | |
| SCHEMBL21413926 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL18009773 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL18205031 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL19696639 | 0.92 | PRMT5 (1.00) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116356032-A | Assay mixtures for predicting the sensitivity of PRMT5 inhibitors to treatment of tumors | 浙江省肿瘤医院 | 2023-06-30 | — | — | CN | claimed |
| CN-116211869-A | Pharmaceutical mixture containing DNA damage repair inhibitor, mixing method and application | 浙江省肿瘤医院 | 2023-06-06 | — | — | CN | claimed |
| CN-116196415-A | Mixed formulations for sensitizing PD-1 antibodies and methods of use thereof | 浙江省肿瘤医院 | 2023-06-02 | — | — | CN | claimed |
| CN-116211869-B | Pharmaceutical mixture containing DNA damage repair inhibitor, mixing method and application | 浙江省肿瘤医院 | 2023-08-01 | — | — | CN | disclosed |
| CN-116196415-B | Mixed formulations for sensitizing PD-1 antibodies and methods of use thereof | 浙江省肿瘤医院 | 2023-08-01 | — | — | CN | disclosed |
| CN-116356032-A | Assay mixtures for predicting the sensitivity of PRMT5 inhibitors to treatment of tumors | 浙江省肿瘤医院 | 2023-06-30 | — | — | CN | disclosed |
| CN-116211869-A | Pharmaceutical mixture containing DNA damage repair inhibitor, mixing method and application | 浙江省肿瘤医院 | 2023-06-06 | — | — | CN | disclosed |
| CN-116196415-A | Mixed formulations for sensitizing PD-1 antibodies and methods of use thereof | 浙江省肿瘤医院 | 2023-06-02 | — | — | CN | disclosed |