Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.38 |
| ▸ | POLR1A | O95602 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 4/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30403448 | 0.97 | TTK (0.39) | TTKPOLR1AEGFRERBB2ERBB3 | |
| SCHEMBL30386170 | 0.93 | TTK (0.38) | TTKPOLR1AEGFRERBB2ERBB3 | |
| SCHEMBL25173677 | 0.88 | TTK (0.40) | TTKPTK6AXL | |
| SCHEMBL22154431 | 0.88 | TTK (0.39) | TTKPTK6AXL | |
| SCHEMBL22123281 | 0.88 | TTK (0.39) | TTKPTK6AXL | |
| SCHEMBL22139156 | 0.88 | TTK (0.39) | TTKPTK6AXL | |
| SCHEMBL22123681 | 0.87 | TTK (0.39) | TTKPTK6AXL | |
| SCHEMBL30385495 | 0.87 | TTK (0.43) | TTKAXL | |
| SCHEMBL24940098 | 0.87 | TTK (0.43) | TTKAXL | |
| SCHEMBL22123713 | 0.87 | TTK (0.43) | TTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161931-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |