Sugi Predict

Sugi Predict / Compounds / SCHEMBL30388264

SCHEMBL30388264

SCHEMBL30388264

Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CBr)cc3)cc3c2cnn3C2CCCC2)c(=O)[nH]1

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 16/20 0.65
▸ EZH1 Q92800 3/20 0.57
▸ EED O75530 2/20 0.54
▸ RBBP4 Q09028 2/20 0.54
▸ SUZ12 Q15022 2/20 0.54
▸ RBBP7 Q16576 2/20 0.54
▸ AEBP2 Q6ZN18 1/20 0.54
▸ PARP1 P09874 1/20 0.53
▸ HDAC1 Q13547 2/20 0.53
▸ HDAC6 Q9UBN7 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12498425 1.00 EZH2 (0.65) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL12498496 0.93 EZH2 (0.66) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL15490984 0.92 EZH2 (0.63) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL2593249 0.91 EZH2 (0.66) EZH2EZH1EEDSUZ12
SCHEMBL2592259 0.90 EZH2 (0.67) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL12498727 0.90 EZH2 (0.70) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL19391445 0.90 EZH2 (0.69) EZH2EZH1HDAC6
SCHEMBL16517927 0.89 EZH2 (0.68) EZH2EZH1HDAC6
SCHEMBL12499131 0.89 EZH2 (0.65) EZH2EZH1EEDRBBP4SUZ12
SCHEMBL12180885 0.88 EZH2 (0.66) EZH2EZH1EEDRBBP4SUZ12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3323820-B1 SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS EPIZYME INC (US) 2023-05-10 — — EP disclosed