Known targets — ChEMBL curated mechanism
PDE10APDE3APDE4APDE4BPDE4CPDE4DPDE5A
The experimentally established mechanism targets of Ibudilast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 7/20 | 1.00 |
| ▸ | PDE5A known ✓ | O76074 | 6/20 | 1.00 |
| ▸ | PDE3A known ✓ | Q14432 | 4/20 | 1.00 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 1.00 |
| ▸ | PDE4C known ✓ | Q08493 | 1/20 | 1.00 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 1.00 |
| ▸ | MIF | P14174 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibudilast SCHEMBL4194864 | 1.00 | PDE4B (1.00) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| Ibudilast SCHEMBL1123689 | 0.97 | PDE4B (0.94) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| Ibudilast SCHEMBL1123688 | 0.97 | PDE4B (0.94) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| Ibudilast SCHEMBL1123710 | 0.93 | PDE4B (0.87) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL3203334 | 0.90 | PDE4B (0.81) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL653193 | 0.88 | PDE4B (0.79) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL7506891 | 0.88 | PDE4B (0.79) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL652912 | 0.88 | PDE4B (0.79) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL10033623 | 0.88 | PDE4B (0.79) | PDE4BPDE5APDE3AMIFALDH1A1 | |
| SCHEMBL652753 | 0.88 | PDE4B (0.79) | PDE4BPDE5APDE3AMIFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8763 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260083702-A1 | INHALATION FORMULATION FOR TREATING IPF DISEASE AND PREPARATION METHOD THEREFOR | SUZHOU INHAL PHARMA CO LTD (CN) | 2026-03-26 | — | — | US | claimed |
| EP-4714433-A1 | INHALATION FORMULATION FOR TREATING IPF DISEASE AND PREPARATION METHOD THEREFOR | Suzhou Inhal Pharma Co., Ltd. (CN) | 2026-03-25 | — | — | EP | claimed |
| US-12582809-B2 | Treatment of a disease of the gastrointestinal tract with a PDE4 inhibitor | BT BIDCO, INC. (US) | 2026-03-24 | — | — | US | claimed |
| US-20260069545-A1 | MODIFIED RELEASE FORMULATIONS OF IBUDILAST | MEDICINOVA, INC. (US) | 2026-03-12 | — | — | US | claimed |
| EP-4704983-A2 | TREATMENT OF MEMORY LOSS WITH PHOSPHODIESTERASE INHIBITORS | Cyrano Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| EP-4695613-A2 | METHODS OF MODIFYING NEURONS IN VIVO TO TREAT AND/OR PREVENT AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Yale University (US) | 2026-02-18 | — | — | EP | claimed |
| US-20260041336-A1 | PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK | NEW YORK UNIVERSITY (US) | 2026-02-12 | — | — | US | claimed |
| US-20260041690-A1 | Treatment of Memory Loss with Phosphodiesterase Inhibitors | CYRANO THERAPEUTICS INC (US) | 2026-02-12 | — | — | US | claimed |
| US-12545948-B2 | Identification of novel loci in asthma and methods of use thereof for the diagnosis and treatment of asthma | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-02-10 | — | — | US | claimed |
| EP-4663205-A1 | POLYMER-DRUG CONJUGATE, INTERMEDIATE THEREOF, AND USE THEREOF | Shanghai Best-Link Bioscience, LLC (CN) | 2025-12-17 | — | — | EP | claimed |
| EP-0215438-B1 | Use of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine for preparing an anti-rheumatic agent | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1991-07-31 | — | — | EP | claimed |
| EP-0156243-B1 | CONTROLLED-RELEASE COMPOSITION AND THE PREPARATION THEREOF | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1990-12-05 | — | — | EP | claimed |
| EP-0375662-A2 | Controlled-release rectal pharmaceutical preparation | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1990-06-27 | — | — | EP | claimed |
| CN-1039355-A | Ibudilast (IBUDILAST) fat microsphere and preparation method thereof | KYORIN SEIYAKU KK (JP) | 1990-02-07 | — | — | CN | claimed |
| EP-0350913-A1 | Ibudilast lipid microsphere and method of preparation thereof | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1990-01-17 | — | — | EP | claimed |
| EP-0319902-A2 | Transdermal Absorptive drug formulation | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1989-06-14 | — | — | EP | claimed |
| EP-0320002-A1 | Inhalant | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1989-06-14 | — | — | EP | claimed |
| US-4735954-A | WITH 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLE(1,5-A) PYRIDINE | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1988-04-05 | — | — | US | claimed |
| EP-0215438-A2 | Use of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine for preparing an anti-rheumatic agent | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1987-03-25 | — | — | EP | claimed |
| EP-0156243-A2 | Controlled-release composition and the preparation thereof | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1985-10-02 | — | — | EP | claimed |