Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100229 | 1.00 | TYK2 (0.39) | TYK2MAPTLMNASMN1; SMN2JAK2 | |
| SCHEMBL30392188 | 0.86 | TYK2 (0.40) | TYK2JAK2PTK2 | |
| SCHEMBL26100976 | 0.86 | TYK2 (0.40) | TYK2JAK2PTK2 | |
| SCHEMBL26099848 | 0.84 | TYK2 (0.47) | TYK2 | |
| SCHEMBL26098880 | 0.83 | SLC2A1 (0.44) | TYK2SLC2A1TP53 | |
| SCHEMBL26102625 | 0.81 | TYK2 (0.41) | TYK2 | |
| SCHEMBL30392501 | 0.81 | TYK2 (0.41) | TYK2 | |
| SCHEMBL26101093 | 0.81 | MAPT (0.34) | TYK2MAPTLMNASMN1; SMN2SLC2A1 | |
| SCHEMBL30392726 | 0.80 | TYK2 (0.40) | TYK2MAPT | |
| SCHEMBL26102885 | 0.80 | TYK2 (0.40) | TYK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |