Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30047586 | 0.80 | EGFR (0.38) | EGFRMAP4K4 | |
| SCHEMBL30003592 | 0.77 | EGFR (0.36) | EGFRRPS6KA5AXL | |
| SCHEMBL1502533 | 0.72 | EGFR (0.47) | EGFRAXL | |
| SCHEMBL2179047 | 0.71 | MAPT (0.58) | EGFRAXL | |
| SCHEMBL1320618 | 0.70 | HTT (0.38) | RPS6KA5 | |
| SCHEMBL31460929 | 0.70 | GRM4 (0.38) | — | |
| SCHEMBL1571411 | 0.70 | ESR1 (0.35) | — | |
| SCHEMBL26679791 | 0.70 | GRM4 (0.38) | — | |
| SCHEMBL17531168 | 0.69 | EGFR (0.36) | EGFRMAP4K4 | |
| SCHEMBL27779914 | 0.69 | ESR1 (0.40) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096710-A | 4-oxo-3, 4-dihydroquinazolinone compounds for the treatment of BRAF related diseases and disorders | 阿雷生物药品公司 | 2023-05-09 | — | — | CN | disclosed |