Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.39 |
| ▸ | KDR | P35968 | 12/20 | 0.39 |
| ▸ | CDK2 | P24941 | 11/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25527803 | 1.00 | CDK1 (0.39) | CDK1KDRCDK2CCNB1CCNA2 | |
| SCHEMBL25527795 | 1.00 | CDK1 (0.39) | CDK1KDRCDK2CCNB1CCNA2 | |
| SCHEMBL25540861 | 0.88 | CDK1 (0.38) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL25527464 | 0.86 | CDK1 (0.52) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL30397324 | 0.86 | CDK1 (0.52) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL25227101 | 0.86 | CDK1 (0.52) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL25227102 | 0.86 | CDK1 (0.52) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL25221186 | 0.85 | CDK1 (0.43) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL30397548 | 0.84 | CDK1 (0.41) | CDK1KDRCDK2CCNB1CDK4 | |
| SCHEMBL25221571 | 0.80 | KDR (0.36) | CDK1KDRCDK2RXFP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |