Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202064 | 1.00 | KDR (0.47) | KDRCDK2CDK1ULK1PTK2 | |
| SCHEMBL25531216 | 0.88 | KDR (0.40) | KDRCDK2CDK1PTK2RXFP1 | |
| SCHEMBL25207890 | 0.88 | SYK (0.43) | KDRCDK2CDK1PTK2LRRK2 | |
| SCHEMBL25209544 | 0.87 | KDR (0.41) | KDRCDK2CDK1PTK2RXFP1 | |
| SCHEMBL25211028 | 0.84 | KDR (0.36) | KDRCDK2CDK1RXFP1AURKA | |
| SCHEMBL25529591 | 0.84 | KDR (0.36) | KDRCDK2CDK1RXFP1AURKA | |
| SCHEMBL30397050 | 0.83 | KDR (0.34) | KDRCDK2CDK1ULK1RXFP1 | |
| SCHEMBL25240089 | 0.83 | KDR (0.34) | KDRCDK2CDK1ULK1RXFP1 | |
| SCHEMBL25521621 | 0.83 | KDR (0.34) | KDRCDK2CDK1ULK1RXFP1 | |
| SCHEMBL25521625 | 0.83 | KDR (0.34) | KDRCDK2CDK1ULK1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |