Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.54 |
| ▸ | CLK1 | P49759 | 11/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.38 |
| ▸ | FLT4 | P35916 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | CLK2 | P49760 | 4/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175184 | 1.00 | DYRK1A (0.54) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL30399726 | 0.90 | DYRK1A (0.51) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL26175183 | 0.90 | DYRK1A (0.51) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL26176371 | 0.90 | DYRK1A (0.45) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL30399669 | 0.90 | DYRK1A (0.45) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL26174722 | 0.85 | TNIK (0.45) | DYRK1ACLK1DYRK1BDYRK2CLK2 | |
| SCHEMBL26175222 | 0.84 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL30399209 | 0.84 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL30400199 | 0.83 | DYRK1A (0.44) | DYRK1ACLK1DYRK1BDYRK2GSK3B | |
| SCHEMBL26175145 | 0.83 | DYRK1A (0.44) | DYRK1ACLK1DYRK1BDYRK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |