Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.43 |
| ▸ | IL2 | P60568 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26177424 | 1.00 | DYRK1A (0.49) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL30399558 | 0.88 | DYRK1A (0.49) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26177423 | 0.88 | DYRK1A (0.49) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL30400428 | 0.87 | DYRK1A (0.52) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26177429 | 0.87 | DYRK1A (0.52) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26175649 | 0.87 | MAP4K1 (0.51) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26177455 | 0.86 | DYRK1A (0.57) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL30400453 | 0.83 | DYRK1A (0.46) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26177436 | 0.83 | DYRK1A (0.46) | DYRK1ACLK2CLK3MAP4K1IL2 | |
| SCHEMBL26174842 | 0.82 | MAP4K1 (0.51) | DYRK1AMAP4K1IL2CLK1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |