Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | CLK3 | P49761 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175152 | 1.00 | DYRK1A (0.48) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL26175112 | 0.95 | DYRK1A (0.47) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL30400619 | 0.95 | DYRK1A (0.47) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL26175151 | 0.89 | MELK (0.46) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL30399215 | 0.89 | MELK (0.46) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL26175154 | 0.89 | MELK (0.46) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL30399574 | 0.89 | MELK (0.46) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL30400110 | 0.88 | MELK (0.48) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL26175153 | 0.88 | MELK (0.48) | DYRK1AMELKGSK3BCLK2CLK3 | |
| SCHEMBL30398632 | 0.87 | DYRK1A (0.48) | DYRK1AMELKGSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |