Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.49 |
| ▸ | CLK1 | P49759 | 10/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175186 | 1.00 | DYRK1A (0.49) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL26175183 | 0.85 | DYRK1A (0.51) | DYRK1ACLK1DYRK1BDYRK2PRKD3 | |
| SCHEMBL30399726 | 0.85 | DYRK1A (0.51) | DYRK1ACLK1DYRK1BDYRK2PRKD3 | |
| SCHEMBL26174724 | 0.85 | HDAC8 (0.45) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL30399311 | 0.83 | DYRK1A (0.42) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL26175107 | 0.83 | DYRK1A (0.42) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL30399776 | 0.81 | DYRK1A (0.45) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL26175224 | 0.81 | DYRK1A (0.45) | DYRK1ACLK1DYRK1BRAF1KCNH2 | |
| SCHEMBL30400709 | 0.80 | RAF1 (0.45) | DYRK1ACLK1RAF1KCNH2HDAC3 | |
| SCHEMBL26177362 | 0.80 | RAF1 (0.45) | DYRK1ACLK1RAF1KCNH2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |