Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 12/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26177069 | 1.00 | ABL1 (0.42) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL26177065 | 0.89 | ABL1 (0.44) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL30400684 | 0.89 | ABL1 (0.44) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL30399830 | 0.87 | GSK3B (0.43) | ABL1GSK3BDYRK1AWNT1 | |
| SCHEMBL26178425 | 0.87 | GSK3B (0.43) | ABL1GSK3BDYRK1AWNT1 | |
| SCHEMBL26177068 | 0.86 | GSK3B (0.59) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL26177064 | 0.86 | GSK3B (0.58) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL30400201 | 0.84 | ABL1 (0.41) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL26177066 | 0.84 | ABL1 (0.41) | ABL1GSK3BDYRK1ACLK1TNIK | |
| SCHEMBL26177072 | 0.84 | GSK3B (0.60) | ABL1GSK3BDYRK1ACLK1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |