Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CCNH | P51946 | 2/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | JAK3 | P52333 | 11/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26176199 | 1.00 | CDK2 (0.49) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL30399648 | 0.88 | FLT3 (0.49) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL26176198 | 0.88 | FLT3 (0.49) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL30398887 | 0.86 | FLT3 (0.51) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL26176202 | 0.86 | FLT3 (0.51) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL30400250 | 0.82 | CDK2 (0.57) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL26176213 | 0.82 | CDK2 (0.57) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL30398855 | 0.82 | DYRK1A (0.45) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL26176203 | 0.82 | DYRK1A (0.45) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL26176219 | 0.81 | CDK2 (0.54) | CDK2FLT3CCNE1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |